AUTHOR=Guo Bei , Zhuang Tongtian , Xu Feng , Lin Xiao , Li Fuxingzi , Shan Su-Kang , Wu Feng , Zhong Jia-Yu , Wang Yi , Zheng Ming-Hui , Xu Qiu-Shuang , Ehsan Ullah Muhammad Hasnain , Yuan Ling-Qing 

TITLE=New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions

JOURNAL=Frontiers in Physiology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2020.570270

DOI=10.3389/fphys.2020.570270

ISSN=1664-042X

ABSTRACT=<p>Adipose tissue, as the largest endocrine organ, secretes many biologically active molecules circulating in the bloodstream, collectively termed adipocytokines, which not only regulate the metabolism but also play a role in pathophysiological processes. C1q tumor necrosis factor (TNF)-related protein 3 (CTRP3) is a member of C1q tumor necrosis factor-related proteins (CTRPs), which is a paralog of adiponectin. CTRP3 has a wide range of effects on glucose/lipid metabolism, inflammation, and contributes to cardiovascular protection. In this review, we comprehensively discussed the latest research on CTRP3 in obesity, diabetes, metabolic syndrome, and cardiovascular diseases.</p>