AUTHOR=Uddin Md. Sahab , Rahman Md. Motiar , Sufian Mohammad Abu , Jeandet Philippe , Ashraf Ghulam Md. , Bin-Jumah May N. , Mousa Shaker A. , Abdel-Daim Mohamed M. , Akhtar Muhammad Furqan , Saleem Ammara , Amran Md. Shah TITLE=Exploring the New Horizon of AdipoQ in Obesity-Related Alzheimer’s Dementia JOURNAL=Frontiers in Physiology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2020.567678 DOI=10.3389/fphys.2020.567678 ISSN=1664-042X ABSTRACT=

Alzheimer’s disease (AD) is the most common form of dementia, which causes abnormalities in learning, thinking, memory, as well as behavior. Generally, symptoms of AD develop gradually and aggravate over time, and consequently severely interfere with daily activities. Furthermore, obesity is one of the common risk factors for dementia. Dysregulation of adipokine and adipocyte dysfunction are assumed to be accountable for the high risk of obesity in people that develop many related disorders such as AD. Moreover, it has been observed that the dysfunction of adipose is connected with changes in brain metabolism, brain atrophy, cognitive decline, impaired mood, neuroinflammation, impaired insulin signaling, and neuronal dysfunction in people with obesity. Conversely, the pathological mechanisms, as well as the molecular players which are involved in this association, have been unclear until now. In this article, we discuss the impact of adiponectin (AdipoQ) on obesity-related Alzheimer’s dementia.