AUTHOR=Yamamoto Sayuri , Kurosaka Hiroshi , Miura Jiro , Aoyama Gozo , Sarper Safiye Esra , Oka Ayaka , Inubushi Toshihiro , Nakatsugawa Kohei , Usami Yu , Toyosawa Satoru , Yamashiro Takashi TITLE=Observation of the Epithelial Cell Behavior in the Nasal Septum During Primary Palate Closure in Mice JOURNAL=Frontiers in Physiology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2020.538835 DOI=10.3389/fphys.2020.538835 ISSN=1664-042X ABSTRACT=
Epithelial fusion is critical in palatogenesis, and incomplete fusion results in various type of facial cleft, depending on the region that fails to fuse. In mammalian palatogenesis, the bilateral secondary palatal processes fuse in the middle of the face to form the secondary palate. Later, the dorsal side of the secondary palatal shelves fuses with the nasal septum to complete palatogenesis. Importantly, the anterior border of the secondary palatal shelf fuses with the primary palate, which is located at the anterior and ventral border of the nasal septum. While numerous studies have investigated the mechanism of fusion between secondary palatal shelves, very little is known about how the primary palate touches and fuses with the secondary palatal shelves. In this study, we investigate the possible epithelial cell behaviors on the surface of the primary palate using palatal explant cultures of