AUTHOR=Chen Mingxian , Li Xuping , Wang Songyun , Yu Lilei , Tang Jianjun , Zhou Shenghua 

TITLE=The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias

JOURNAL=Frontiers in Physiology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2020.01113

DOI=10.3389/fphys.2020.01113

ISSN=1664-042X

ABSTRACT=<p>In the heart, cardiac macrophages have widespread biological functions, including roles in antigen presentation, phagocytosis, and immunoregulation, through the formation of diverse cytokines and growth factors; thus, these cells play an active role in tissue repair after heart injury. Recent clinical studies have indicated that macrophages or elevated inflammatory cytokines secreted by macrophages are closely related to ventricular arrhythmias (VAs). This review describes the role of macrophages and macrophage-secreted inflammatory cytokines in ventricular arrhythmogenesis.</p>