AUTHOR=Kwon Sun Hyung , Barrera Janos A. , Noishiki Chikage , Chen Kellen , Henn Dominic , Sheckter Clifford C. , Gurtner Geoffrey C. 

TITLE=Current and Emerging Topical Scar Mitigation Therapies for Craniofacial Burn Wound Healing

JOURNAL=Frontiers in Physiology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2020.00916

DOI=10.3389/fphys.2020.00916

ISSN=1664-042X

ABSTRACT=<p>Burn injury in the craniofacial region causes significant health and psychosocial consequences and presents unique reconstructive challenges. Healing of severely burned skin and underlying soft tissue is a dynamic process involving many pathophysiological factors, often leading to devastating outcomes such as the formation of hypertrophic scars and debilitating contractures. There are limited treatment options currently used for post-burn scar mitigation but recent advances in our knowledge of the cellular and molecular wound and scar pathophysiology have allowed for development of new treatment concepts. Clinical effectiveness of these experimental therapies is currently being evaluated. In this review, we discuss current topical therapies for craniofacial burn injuries and emerging new therapeutic concepts that are highly translational.</p>