AUTHOR=Poteres Elesa , Hubert Nathaniel , Poludasu Sudeep , Brigando Gabriella , Moore Julia , Keeler Kelly , Isabelli Allison , Ibay Iara Cassandra V. , Alt Lauren , Pytynia Matthew , Ciancio Mae , Martinez-Guryn Kristina TITLE=Selective Regional Alteration of the Gut Microbiota by Diet and Antibiotics JOURNAL=Frontiers in Physiology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2020.00797 DOI=10.3389/fphys.2020.00797 ISSN=1664-042X ABSTRACT=
The small intestinal microbiota has recently been implicated in contributing to metabolic disease. We previously demonstrated that diets rich in saturated milk fat have a particularly strong impact on the small bowel microbiota as opposed to more distal gastrointestinal (GI) regions. However, the impact of antibiotics and diet on the small bowel microbiota has not been clearly demonstrated. Thus, we sought to determine how diet and antibiotics interact in modulating the regional landscape of the gut microbiota. We conducted a study using male mice on a high fat (HF) or a low fat (LF) diet (