AUTHOR=van der Horst Jennifer , Greenwood Iain A. , Jepps Thomas A. 

TITLE=Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels

JOURNAL=Frontiers in Physiology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2020.00727

DOI=10.3389/fphys.2020.00727

ISSN=1664-042X

ABSTRACT=<p>Voltage-gated Kv7 potassium channels, encoded by <italic>KCNQ</italic> genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic adenosine monophosphate (cAMP), a well-known intracellular secondary messenger, can activate numerous downstream effector proteins, generating downstream signaling pathways that regulate many functions in cells. A role for cAMP in ion channel regulation has been established, and recent findings show that cAMP signaling plays a role in Kv7 channel regulation. Although cAMP signaling is recognized to regulate Kv7 channels, the precise molecular mechanism behind the cAMP-dependent regulation of Kv7 channels is complex. This review will summarize recent research findings that support the mechanisms of cAMP-dependent regulation of Kv7 channels.</p>