AUTHOR=Ishii Shuya , Oyama Kotaro , Shintani Seine A. , Kobirumaki-Shimozawa Fuyu , Ishiwata Shin’ichi , Fukuda Norio 

TITLE=Thermal Activation of Thin Filaments in Striated Muscle

JOURNAL=Frontiers in Physiology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2020.00278

DOI=10.3389/fphys.2020.00278

ISSN=1664-042X

ABSTRACT=<p>In skeletal and cardiac muscles, contraction is triggered by an increase in the intracellular Ca<sup>2+</sup> concentration. During Ca<sup>2+</sup> transients, Ca<sup>2+</sup>-binding to troponin C shifts the “<italic>on–off</italic>” equilibrium of the thin filament state toward the “<italic>on</italic>” sate, promoting actomyosin interaction. Likewise, recent studies have revealed that the thin filament state is under the influence of temperature; <italic>viz.</italic>, an increase in temperature increases active force production. In this short review, we discuss the effects of temperature on the contractile performance of mammalian striated muscle at/around body temperature, focusing especially on the temperature-dependent shift of the “<italic>on–off</italic>” equilibrium of the thin filament state.</p>