AUTHOR=Stoyell-Conti Filipe Fernandes , Irigoyen Maria-Claudia , Sartori Michelle , Ribeiro Amanda Aparecida , dos Santos Fernando , Machi Jacqueline Freire , Figueroa Diego Mendrot Taboas , Rodrigues Bruno , De Angelis Kátia 

TITLE=Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice

JOURNAL=Frontiers in Physiology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2019.01464

DOI=10.3389/fphys.2019.01464

ISSN=1664-042X

ABSTRACT=<p><bold>Objective:</bold> This study evaluated the effects of aerobic, resistance, and combined exercise training on cardiac function and autonomic modulation in female ob/ob mice.</p><p><bold>Methods:</bold> Four-week-old female wild type and obese (ob/ob) mice were divided into five groups (<italic>n</italic> = 8): control (WT), obese (OB) obese + aerobic training (OBA), obese + resistance training (OBR), and obese + combined training (OBC). The exercise training was performed on treadmill and/or ladder at 40–60% maximum test during 8 weeks. Cardiac function was measured using echo machine. Heart rate variability (HRV) was evaluated in the time and frequency domain.</p><p><bold>Results:</bold> OB group presented higher body weight gain (~600%), glycemia (~44%) and glucose intolerance (~150%), reduction of cardiac vagal modulation, evidenced by a lower RMMSD (~56%), total power and high frequency band, and a higher isovolumic relaxation time (IVRT) (~24%) in relation to the WT group. Aerobic and combined training led to a lower IVRT (OBA: ~14%; OBC: ~14%) and myocardial global index (OBA: ~37%; OBC: ~44%). The OBA group presented an increased in vagal indexes of HRV than the other ob/ob groups. A negative correlation was observed between the delta of aerobic exercise capacity and MPI (<italic>r</italic> = 0.45; <italic>p</italic> = 0.002) and exercise capacity and body weight gain (<italic>r</italic> = 0.39; <italic>p</italic> = 0.002).</p><p><bold>Conclusion:</bold> Only the obese females underwent to aerobic exercise training showed improvement in cardiac function and HRV. Moreover, the aerobic exercise capacity as well as a greater responsivity to aerobic exercise training is intimately associated with these improvements, reinforcing the importance of aerobic exercise training to this population.</p>