AUTHOR=Ding Sujuan , Ma Yong , Liu Gang , Yan Wenxin , Jiang Hongmei , Fang Jun 

TITLE=Lactobacillus brevis Alleviates DSS-Induced Colitis by Reprograming Intestinal Microbiota and Influencing Serum Metabolome in Murine Model

JOURNAL=Frontiers in Physiology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2019.01152

DOI=10.3389/fphys.2019.01152

ISSN=1664-042X

ABSTRACT=<p>The aim of this study was to examine the effects of <italic>Lactobacillus brevis</italic> on the microbial community and serum metabolome in colitis induced by dextran sulfate sodium (DSS). ICR mice were randomly distributed into three treatment groups: (i) <italic>L. brevis</italic> treatment alone (control), (ii) DSS administration alone, and (iii) treatment with <italic>L. brevis</italic> and DSS. Our results demonstrate that <italic>L. brevis</italic> treatment significantly alleviated DSS-induced body weight loss and colon inflammation. In addition, LC-MS analysis of serum metabolites revealed that <italic>L. brevis</italic> treatment increased the serum level of metabolites against inflammatory responses or oxidative stressors caused by DSS in the murine model. By detecting colonic microbiota, <italic>L. brevis</italic> increased colonic microbial diversity after challenging with DSS, and increased the relative abundance of Alloprevotella at genus, but Bacteroidales was reduced (<italic>P</italic> &lt; 0.05). These result indicated that <italic>L. brevis</italic> could lower the severity of colitis induced by DSS via improving reprogramming the serum metabolome and intestinal microbiota. These findings suggest that the probiotic <italic>L. brevis</italic> may prevent tissue damage from colitis.</p>