AUTHOR=Fan Xuehui , Sun Tianyi , Crawford William , Tan Xiaoqiu , Ou Xianhong , Terrar Derek A. , Ebert Steven N. , Lei Ming 

TITLE=Pnmt-Derived Cardiomyocytes: Anatomical Localization, Function and Future Perspectives

JOURNAL=Frontiers in Physiology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2019.00713

DOI=10.3389/fphys.2019.00713

ISSN=1664-042X

ABSTRACT=<p>In this mini-review, we provide an overview of phenylethanolamine-N-methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs), a recently discovered cardiomyocyte subpopulation. We discuss their anatomical localization, physiological characteristics, possible function, and future perspectives. Their unique distribution in the heart, electrical activity, Ca<sup>2+</sup> transient properties, and potential role in localized adrenergic signaling are discussed.</p>