AUTHOR=Song Jiajia , Yang Ruilin , Yang Jing , Zhou Lufang TITLE=Mitochondrial Dysfunction-Associated Arrhythmogenic Substrates in Diabetes Mellitus JOURNAL=Frontiers in Physiology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.01670 DOI=10.3389/fphys.2018.01670 ISSN=1664-042X ABSTRACT=

There is increasing evidence that diabetic cardiomyopathy increases the risk of cardiac arrhythmia and sudden cardiac death. While the detailed mechanisms remain incompletely understood, the loss of mitochondrial function, which is often observed in the heart of patients with diabetes, has emerged as a key contributor to the arrhythmogenic substrates. In this mini review, the pathophysiology of mitochondrial dysfunction in diabetes mellitus is explored in detail, followed by descriptions of several mechanisms potentially linking mitochondria to arrhythmogenesis in the context of diabetic cardiomyopathy.