AUTHOR=He Wei-Ling , Weng Xiang-Tao , Wang Jue-Lian , Lin Yong-Kai , Liu Tian-Wen , Zhou Qian-Yi , Hu Yue , Pan Yunbao , Chen Xin-Lin 

TITLE=Association Between c-Myc and Colorectal Cancer Prognosis: A Meta-Analysis

JOURNAL=Frontiers in Physiology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.01549

DOI=10.3389/fphys.2018.01549

ISSN=1664-042X

ABSTRACT=<p><bold>Background:</bold> There is debate as to whether c-Myc predicts prognosis in colorectal cancer (CRC). In this study, we aimed to review the association between c-Myc and CRC prognosis.</p><p><bold>Methods:</bold> Pertinent studies were identified by searching electronic databases and carefully reviewing the reference lists of pertinent studies until March 2016. The summary hazard ratio (HR) and corresponding 95% confidence interval (CI) were calculated to study the association between c-Myc and CRC prognosis.</p><p><bold>Results:</bold> Eight cohort studies (including seven studies about overall survival [OS] and one study about disease free survival [DFS]) were included. The pooled HR of OS was 1.13 (95% CI: 0.66–1.95). In subgroup analysis, no significant association between c-Myc and CRC prognosis was found in the studies either from Western countries (HR: 0.87, 95% CI: 0.68–1.10) or Asian countries (HR: 1.89, 95% CI: 0.62–5.77). HRs were 0.86 (95% CI: 0.38–1.94) and 1.57 (95% CI: 0.73–3.39) for the studies using univariate analysis and multivariate analysis, respectively. HR from the studies that examined DNA level was significantly different (HR: 2.05, 95% CI: 1.22–3.46); while that about RNA level or protein level was not significantly different.</p><p><bold>Conclusion:</bold> c-Myc was not associated with CRC prognosis in this meta-analysis. However, the conclusion is preliminary and should be examined in future studies.</p>