AUTHOR=Xie Wen-Zhong , Jin Ying-Hui , Leng Wei-Dong , Wang Xing-Huan , Zeng Xian-Tao ,  BPSC investigators 

TITLE=Periodontal Disease and Risk of Bladder Cancer: A Meta-Analysis of 298476 Participants

JOURNAL=Frontiers in Physiology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.00979

DOI=10.3389/fphys.2018.00979

ISSN=1664-042X

ABSTRACT=<p><bold>Objective:</bold> It has been reported that the periodontal disease is linked to a number of malignant tumors such as lung cancer and pancreatic cancer. In this study, we aimed to investigate the association of periodontal disease with risk of bladder cancer by a meta-analysis.</p><p><bold>Methods:</bold> PubMed, Scopus, ScienceDirect, and Chinese National Knowledge Infrastructure (CNKI) were searched for eligible publications up to December 15, 2017. Cohort and nested case-control studies on the association between periodontal disease and risk of bladder cancer were included. After study selection and data extraction, pooled hazard ratios (HRs) and their 95% confidence intervals (95%CIs) were calculated using a fixed-effect inverse-variance model. All analyses were performed using the RevMan 5.3 software.</p><p><bold>Results:</bold> Finally, five cohort studies were identified and included in this meta-analysis, involving 1,104 bladder cancer cases of 298,476 participants. Summary estimates based on adjusted data showed that periodontal disease was not significantly associated with the risk of bladder cancer (<italic>HR</italic> = 1.09, 95% CI = 0.95–1.25, <italic>I</italic><sup>2</sup> = 0%). A similar result was also observed after cumulative, subgroup and sensitivity analyses.</p><p><bold>Conclusions:</bold> Current evidence from cohort studies suggests that patients with periodontal disease may not be at an increased risk of developing bladder cancer.</p>