AUTHOR=Lanza Fernanda C. , Reimberg Mariana M. , Ritti-Dias Raphael , Scalco Rebeca S. , Wandalsen Gustavo F. , Sole Dirceu , van Brussel Marco , Hulzebos H. J. , Dal Corso Simone , Takken Tim TITLE=Validation of the Modified Shuttle Test to Predict Peak Oxygen Uptake in Youth Asthma Patients Under Regular Treatment JOURNAL=Frontiers in Physiology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.00919 DOI=10.3389/fphys.2018.00919 ISSN=1664-042X ABSTRACT=

Background: Oxygen uptake (VO₂) evaluations by cardiopulmonary exercise test is expensive and time-consuming. Estimating VO₂ based on a field test would be an alternative.

Objective: To develop and validate an equation to predict VO_2peak based on the modified shuttle test (MST).

Methods: Cross sectional study, with 97 children and adolescents with asthma. Participants were divided in two groups: the equation group (EG), to construct the equation model of VO_2peak, and the cross-validation group (VG). Each subject performed the MST twice using a portable gas analyzer. The peak VO_2peak during MST was used in the equation model. The patients’ height, weight, gender, and distance walked (DW) during MST were tested as independent variables.

Results: The final model [-0.457 + (gender × 0.139) + (weight × 0.025) + (DW × 0.002)] explained 87% of VO_2peak variation. The VO_2peak predicted was similar to VO_2peak measured by gas analyzer (1.9 ± 0.5 L/min and 2.0 ± 0.5 L/min, respectively) (p = 0.67), and presented significant ICC 0.91 (IC95% 0.77 to 0.96); p < 0.001. The Bland–Altman analysis showed low bias (-0.15 L/min) and limits of agreement (-0.65 to 0.35 L/min). There was no difference in DW between EG (760 ± 209 m) and VG (731 ± 180 m), p = 0.51.

Conclusion: The developed equation adequately predicts VO_2peak in pediatric patients with asthma.