AUTHOR=Jois Shreyas , Chan Yick Bun , Fernandez Maria Paz , Leung Adelaine Kwun-Wai 

TITLE=Characterization of the Sexually Dimorphic fruitless Neurons That Regulate Copulation Duration

JOURNAL=Frontiers in Physiology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.00780

DOI=10.3389/fphys.2018.00780

ISSN=1664-042X

ABSTRACT=<p>Male courtship in <italic>Drosophila melanogaster</italic> is a sexually dimorphic innate behavior that is hardwired in the nervous system. Understanding the neural mechanism of courtship behavior requires the anatomical and functional characterization of all the neurons involved. Courtship involves a series of distinctive behavioral patterns, culminating in the final copulation step, where sperms from the male are transferred to the female. The duration of this process is tightly controlled by multiple genes. The <italic>fruitless</italic> (<italic>fru</italic>) gene is one of the factors that regulate the duration of copulation. Using several intersectional genetic combinations to restrict the labeling of GAL4 lines, we found that a subset of a serotonergic cluster of <italic>fru</italic> neurons co-express the dopamine-synthesizing enzyme, tyrosine hydroxylase, and provide behavioral and immunological evidence that these neurons are involved in the regulation of copulation duration.</p>