AUTHOR=Naldi Aurélien , Hernandez Céline , Abou-Jaoudé Wassim ,  Monteiro Pedro T. , Chaouiya Claudine , Thieffry Denis 

TITLE=Logical Modeling and Analysis of Cellular Regulatory Networks With GINsim 3.0

JOURNAL=Frontiers in Physiology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.00646

DOI=10.3389/fphys.2018.00646

ISSN=1664-042X

ABSTRACT=<p>The logical formalism is well adapted to model large cellular networks, in particular when detailed kinetic data are scarce. This tutorial focuses on this well-established qualitative framework. Relying on GINsim (release 3.0), a software implementing this formalism, we guide the reader step by step toward the definition, the analysis and the simulation of a four-node model of the mammalian p53-Mdm2 network.</p>