AUTHOR=Han June-Chiew , Guild Sarah-Jane , Pham Toan , Nisbet Linley , Tran Kenneth , Taberner Andrew J. , Loiselle Denis S. TITLE=Left-Ventricular Energetics in Pulmonary Arterial Hypertension-Induced Right-Ventricular Hypertrophic Failure JOURNAL=Frontiers in Physiology VOLUME=8 YEAR=2018 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2017.01115 DOI=10.3389/fphys.2017.01115 ISSN=1664-042X ABSTRACT=
Pulmonary arterial hypertension (PAH) alters the geometries of both ventricles of the heart. While the right ventricle (RV) hypertrophies, the left ventricle (LV) atrophies. Multiple lines of clinical and experimental evidence lead us to hypothesize that the impaired stroke volume and systolic pressure of the LV are a direct consequence of the effect of pressure overload in the RV, and that atrophy in the LV plays only a minor role. In this study, we tested this hypothesis by examining the mechanoenergetic response of the atrophied LV to RV hypertrophy in rats treated with monocrotaline. Experiments were performed across multiple-scales: the whole-heart