AUTHOR=Razzak Muhammad Abdur , Hossain Md. Sanower , Radzi Zamri Bin , Yahya Noor Azlin B. , Czernuszka Jan , Rahman Mohammad T. TITLE=Cellular and Molecular Responses to Mechanical Expansion of Tissue JOURNAL=Frontiers in Physiology VOLUME=7 YEAR=2016 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2016.00540 DOI=10.3389/fphys.2016.00540 ISSN=1664-042X ABSTRACT=

The increased use of tissue expander in the past decades and its potential market values in near future give enough reasons to sum up the consequences of tissue expansion. Furthermore, the patients have the right to know underlying mechanisms of adaptation of inserted biomimetic, its bioinspired materials and probable complications. The mechanical strains during tissue expansion are related to several biological phenomena. Tissue remodeling during the expansion is highly regulated and depends on the signal transduction. Any alteration may lead to tumor formation, necrosis and/or apoptosis. In this review, stretch induced cell proliferation, apoptosis, the roles of growth factors, stretch induced ion channels, and roles of second messengers are organized. It is expected that readers from any background can understand and make a decision about tissue expansion.