AUTHOR=Zhang Cheng , Hua Qiang 

TITLE=Applications of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine

JOURNAL=Frontiers in Physiology

VOLUME=6

YEAR=2016

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2015.00413

DOI=10.3389/fphys.2015.00413

ISSN=1664-042X

ABSTRACT=<p>Genome-scale metabolic models (GEMs) have become a popular tool for systems biology, and they have been used in many fields such as industrial biotechnology and systems medicine. Since more and more studies are being conducted using GEMs, they have recently received considerable attention. In this review, we introduce the basic concept of GEMs and provide an overview of their applications in biotechnology, systems medicine, and some other fields. In addition, we describe the general principle of the applications and analyses built on GEMs. The purpose of this review is to introduce the application of GEMs in biological analysis and to promote its wider use by biologists.</p>