AUTHOR=Salmina Alla B. , Komleva Yulia K. , Szijártó István A. , Gorina Yana V. , Lopatina Olga L. , Gertsog Galina E. , Filipovic Milos R. , Gollasch Maik 

TITLE=H2S- and NO-Signaling Pathways in Alzheimer's Amyloid Vasculopathy: Synergism or Antagonism?

JOURNAL=Frontiers in Physiology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2015.00361

DOI=10.3389/fphys.2015.00361

ISSN=1664-042X

ABSTRACT=<p>Alzheimer's type of neurodegeneration dramatically affects H<sub>2</sub>S and NO synthesis and interactions in the brain, which results in dysregulated vasomotor function, brain tissue hypoperfusion and hypoxia, development of perivascular inflammation, promotion of Aβ deposition, and impairment of neurogenesis/angiogenesis. H<sub>2</sub>S- and NO-signaling pathways have been described to offer protection against Alzheimer's amyloid vasculopathy and neurodegeneration. This review describes recent developments of the increasing relevance of H<sub>2</sub>S and NO in Alzheimer's disease (AD). More studies are however needed to fully determine their potential use as therapeutic targets in Alzheimer's and other forms of vascular dementia.</p>