AUTHOR=Freitas Lima Leandro C. , Braga Valdir de Andrade , do Socorro de França Silva Maria , Cruz Josiane de Campos , Sousa Santos Sérgio H. , de Oliveira Monteiro Matheus M. , Balarini Camille de Moura 

TITLE=Adipokines, diabetes and atherosclerosis: an inflammatory association

JOURNAL=Frontiers in Physiology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2015.00304

DOI=10.3389/fphys.2015.00304

ISSN=1664-042X

ABSTRACT=<p>Cardiovascular diseases can be considered the most important cause of death in diabetic population and diabetes can in turn increase the risk of cardiovascular events. Inflammation process is currently recognized as responsible for the development and maintenance of diverse chronic diseases, including diabetes and atherosclerosis. Considering that adipose tissue is an important source of adipokines, which may present anti and proinflammatory effects, the aim of this review is to explore the role of the main adipokines in the pathophysiology of diabetes and atherosclerosis, highlighting the therapeutic options that could arise from the manipulation of these signaling pathways both in humans and in translational models.</p>