AUTHOR=Santulli Gaetano , IACCARINO Guido , De Luca Nicola , Trimarco Bruno , Condorelli Gianluigi 

TITLE=Atrial fibrillation and microRNAs

JOURNAL=Frontiers in Physiology

VOLUME=5

YEAR=2014

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2014.00015

DOI=10.3389/fphys.2014.00015

ISSN=1664-042X

ABSTRACT=<p>Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This report represents a systematic and updated appraisal of the main studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue.</p>