AUTHOR=Ravindran Sriram , Huang Chun-Chieh , GEORGE ANNE TITLE=Extracellular matrix of dental pulp stem cells: applications in pulp tissue engineering using somatic MSCs JOURNAL=Frontiers in Physiology VOLUME=4 YEAR=2014 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2013.00395 DOI=10.3389/fphys.2013.00395 ISSN=1664-042X ABSTRACT=
Dental Caries affects approximately 90% of the world's population. At present, the clinical treatment for dental caries is root canal therapy. This treatment results in loss of tooth sensitivity and vitality. Tissue engineering can potentially solve this problem by enabling regeneration of a functional pulp tissue. Dental pulp stem cells (DPSCs) have been shown to be an excellent source for pulp regeneration. However, limited availability of these cells hinders its potential for clinical translation. We have investigated the possibility of using somatic mesenchymal stem cells (MSCs) from other sources for dental pulp tissue regeneration using a biomimetic dental pulp extracellular matrix (ECM) incorporated scaffold. Human periodontal ligament stem cells (PDLSCs) and human bone marrow stromal cells (HMSCs) were investigated for their ability to differentiate toward an odontogenic lineage.