AUTHOR=Xin Li , Bai Donglin TITLE=Functional roles of the amino terminal domain in determining biophysical properties of Cx50 gap junction channels JOURNAL=Frontiers in Physiology VOLUME=4 YEAR=2013 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2013.00373 DOI=10.3389/fphys.2013.00373 ISSN=1664-042X ABSTRACT=
Communication through gap junction channels is essential for synchronized and coordinated cellular activities. The gap junction channel pore size, its switch control for opening/closing, and the modulations by chemicals can be different depending on the connexin subtypes that compose the channel. Recent structural and functional studies provide compelling evidence that the amino terminal (NT) domains of several connexins line the pore of gap junction channels and play an important role in single channel conductance (γ