AUTHOR=Menzies Robert I., Unwin Robert J., Dash Ranjan K., Beard Daniel A., Cowley Allen W., Carlson Brian E., Mullins John J., Bailey Matthew A. TITLE=Effect of P2X4 and P2X7 receptor antagonism on the pressure diuresis relationship in rats JOURNAL=Frontiers in Physiology VOLUME=4 YEAR=2013 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2013.00305 DOI=10.3389/fphys.2013.00305 ISSN=1664-042X ABSTRACT=
Reduced glomerular filtration, hypertension and renal microvascular injury are hallmarks of chronic kidney disease, which has a global prevalence of ~10%. We have shown previously that the Fischer (F344) rat has lower GFR than the Lewis rat, and is more susceptible to renal injury induced by hypertension. In the early stages this injury is limited to the pre-glomerular vasculature. We hypothesized that poor renal hemodynamic function and vulnerability to vascular injury are causally linked and genetically determined. In the present study, normotensive F344 rats had a blunted pressure diuresis relationship, compared with Lewis rats. A kidney microarray was then interrogated using the Endeavour enrichment tool to rank candidate genes for impaired blood pressure control. Two novel candidate genes,