AUTHOR=Jacobs Mollie E., Wingo Charles S., Cain Brian D.

TITLE=An emerging role for microRNA in the regulation of endothelin-1

JOURNAL=Frontiers in Physiology

VOLUME=4

YEAR=2013

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2013.00022

DOI=10.3389/fphys.2013.00022

ISSN=1664-042X

ABSTRACT=<p>Endothelin-1 (ET-1) is a peptide signaling molecule serving diverse functions in many different tissues such as the vasculature and the kidney. The primary mechanism thought to control ET-1 bioavailability is the rate of transcription from the ET-1 gene (<italic>EDN1</italic>), but recent research suggests that <italic>EDN1</italic> expression is attenuated by microRNA (miRNA)—mediated regulation. The action of specific miRNAs on <italic>EDN1</italic> mRNA appears to vary greatly in a tissue specific manner. This review provides a summary of our current understanding of miRNA-<italic>EDN1</italic> interaction.</p>