AUTHOR=Wilhelms Mathias , Hettmann Hanne , Maleckar Mary M., Koivumäki Jussi T., Dössel Olaf , Seemann Gunnar TITLE=Benchmarking electrophysiological models of human atrial myocytes JOURNAL=Frontiers in Physiology VOLUME=3 YEAR=2013 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2012.00487 DOI=10.3389/fphys.2012.00487 ISSN=1664-042X ABSTRACT=

Mathematical modeling of cardiac electrophysiology is an insightful method to investigate the underlying mechanisms responsible for arrhythmias such as atrial fibrillation (AF). In past years, five models of human atrial electrophysiology with different formulations of ionic currents, and consequently diverging properties, have been published. The aim of this work is to give an overview of strengths and weaknesses of these models depending on the purpose and the general requirements of simulations. Therefore, these models were systematically benchmarked with respect to general mathematical properties and their ability to reproduce certain electrophysiological phenomena, such as action potential (AP) alternans. To assess the models' ability to replicate modified properties of human myocytes and tissue in cardiac disease, electrical remodeling in chronic atrial fibrillation (cAF) was chosen as test case. The healthy and remodeled model variants were compared with experimental results in single-cell, 1D and 2D tissue simulations to investigate AP and restitution properties, as well as the initiation of reentrant circuits.