AUTHOR=Piras Vincent , Tomita Masaru , Selvarajoo Kumar 

TITLE=Is central dogma a global property of cellular information flow?

JOURNAL=Frontiers in Physiology

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2012.00439

DOI=10.3389/fphys.2012.00439

ISSN=1664-042X

ABSTRACT=<p>The central dogma of molecular biology has come under scrutiny in recent years. Here, we reviewed high-throughput mRNA and protein expression data of <italic>Escherichia coli, Saccharomyces cerevisiae</italic>, and several mammalian cells. At both single cell and population scales, the statistical comparisons between the entire transcriptomes and proteomes show clear correlation structures. In contrast, the pair-wise correlations of single transcripts to proteins show nullity. These data suggest that the organizing structure guiding cellular processes is observed at omics-wide scale, and not at single molecule level. The central dogma, thus, globally emerges as an average integrated flow of cellular information.</p>