AUTHOR=Sankaranarayanan Rajiv , Venetucci Luigi 

TITLE=Are the anti-arrhythmic effects of omega-3 fatty acids due to modulation of myocardial calcium handling?

JOURNAL=Frontiers in Physiology

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2012.00373

DOI=10.3389/fphys.2012.00373

ISSN=1664-042X

ABSTRACT=<p>Both animal and clinical studies have demonstrated that omega-3 fatty acids have anti-arrhythmic properties. It has been suggested that these anti-arrhythmic effects are due to modulation of the activity of various myocardial calcium handling proteins such as ryanodine receptor (RyR), L-type calcium current and sodium/calcium exchanger. In this article, we review all the data available on the effects of omega-3 fatty acids on ventricular myocardial calcium handling. In addition we highlight some unanswered questions and discuss possible therapeutic benefits of omega-3 fatty acids.</p>