AUTHOR=HIBAOUI Youssef , Feki Anis 

TITLE=Human Pluripotent Stem Cells: Applications and Challenges in Neurological Diseases

JOURNAL=Frontiers in Physiology

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2012.00267

DOI=10.3389/fphys.2012.00267

ISSN=1664-042X

ABSTRACT=<p>The ability to generate human pluripotent stem cells (hPSCs) holds great promise for the understanding and the treatment of human neurological diseases in modern medicine. The hPSCs are considered for their <italic>in vitro</italic> use as research tools to provide relevant cellular model for human diseases, drug discovery, and toxicity assays and for their <italic>in vivo</italic> use in regenerative medicine applications. In this review, we highlight recent progress, promises, and challenges of hPSC applications in human neurological disease modeling and therapies.</p>