AUTHOR=Aranega Amelia E., de la Rosa Angel J., Franco Diego 

TITLE=Cardiac Conduction System Anomalies and Sudden Cardiac Death: Insights from Murine Models

JOURNAL=Frontiers in Physiology

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2012.00211

DOI=10.3389/fphys.2012.00211

ISSN=1664-042X

ABSTRACT=<p>The cardiac conduction system (CCS) is composed of a group of myocardial tissues that control and coordinate the heart. Alterations in the CCS – especially in the His–Purkinje system, have been identified as a major cause of lethal arrhythmias. Unstable arrhythmias secondary to channelopathies significantly increase the risk of sudden cardiac death (SCD). SCD is a major contributor to mortality in industrialized countries, and most cases of SCD in the young are related to inherited ion channel diseases. In this paper, we review a series of studies with murine transgenic models that revealed that some arrhythmias are associated with the CCS and may lead to SCD</p>