AUTHOR=Nishikawa Sumio , Abe Michio 

TITLE=Immunocytochemical Localization of Claudin-1 in the Maturation Ameloblasts of Rat Incisors

JOURNAL=Frontiers in Physiology

VOLUME=1

YEAR=2010

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2010.00150

DOI=10.3389/fphys.2010.00150

ISSN=1664-042X

ABSTRACT=<p>Claudin-1 is a tight junction transmembrane protein. Its localization in the maturation ameloblasts of rat incisors was examined by immunofluorescence microscopy. Distal junction area of ruffle-ended ameloblasts (RA) and the Golgi apparatus of a sub-population of smooth-ended ameloblasts (SA) and RAs stained positive with anti-claudin-1 antibodies. Since it has been shown that ameloblasts repeatedly alternate between an SA and an RA morphology during enamel maturation, the presence of claudin-1 in the Golgi cisterns may indicate the presence of tight junction precursors before transportation to the junctional area.</p>