AUTHOR=Cardounel Arturo J. TITLE=Grand challenge: investigating the oxidant hypothesis in the realm of systems physiology and disease pathogenesis JOURNAL=Frontiers in Physiology VOLUME=1 YEAR=2010 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2010.00004 DOI=10.3389/fphys.2010.00004 ISSN=1664-042X