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ORIGINAL RESEARCH article

Front. Phys.
Sec. Medical Physics and Imaging
Volume 12 - 2024 | doi: 10.3389/fphy.2024.1450631
This article is part of the Research Topic Pushing The Physical Limits Of Wave Propagation In Soft Tissues: An Add-On To Shear Wave Elastography View all 6 articles

Detection of Natural Pulse Waves (PWs) in 3D using high frame rate imaging for Anisotropy characterization

Provisionally accepted
Jack Sauvage Jack Sauvage 1Safa Moustefaoui Safa Moustefaoui 1Stefano Fiorentini Stefano Fiorentini 2Maelys Venet Maelys Venet 3Solveig Fadnes Solveig Fadnes 2Lasse Lovastakken Lasse Lovastakken 2Olivier Villemain Olivier Villemain 3,4Sebastien Salles Sebastien Salles 1,3,5*
  • 1 Laboratory of biomedical imaging - CNRS, Paris, France
  • 2 Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Sør-Trøndelag, Norway
  • 3 INSERM Institut de Rythmologie et Modélisation Cardiaque (IHU-Liryc), Pessac, France
  • 4 Département de pédiatrie, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France
  • 5 UMR5536 Centre de Resonance Magnetique des Systemes Biologiques (CRMSB), Bordeaux, Aquitaine, France

The final, formatted version of the article will be published soon.

    Numerous studies have shown that natural mechanical waves have the potential to assess the elastic properties of the myocardium. When the Aortic and Mitral valves close, a shear wave is produced, which provides insights into tissue stiffness. In addition, the Atrial Kick (AK) generates a wave similar to Pulse Waves (PWs) in arteries, providing another way to assess tissue stiffness. However, tissue anisotropy can also impact PW propagation, which is currently underexplored. This study aims to address this gap by investigating the impact of anisotropy on PW propagation in a phantom. Tube phantoms were created using Polyvinyl Alcohol (PVA). Anisotropy was induced between two sets of two freeze-thaw cycles by stretching and twisting the material. The study first tests and validates the procedure of making an anisotropic vessel phantom using the shear wave imaging technique (by estimating the shear wave speed at different probe angles). Using plane wave ultrasound tomography synchronized with a peristaltic pump, 3D high frame rate imaging is performed and used to detect the 3D propagation pattern of PW for each manufactured vessel phantom. Finally, the study attempts to extract the anisotropic coefficient of the vessel using pulse wave propagation. The results show that anisotropy can be induced in PVA vessel phantoms by stretching and twisting. As well known for other tissues, such as the myocardium, the findings also suggest that vessel anisotropy affects pulse wave propagation. Finally, as a potential method for extracting vessel anisotropy, we propose an anisotropy coefficient that reflects the number of circumferential turns during vessel fabrication.

    Keywords: Cardio-Vascular1, Ultrafast Ultrasound Imaging2, Pulse Wave 3, Anisotropy4, Vessel phantom5

    Received: 17 Jun 2024; Accepted: 30 Aug 2024.

    Copyright: © 2024 Sauvage, Moustefaoui, Fiorentini, Venet, Fadnes, Lovastakken, Villemain and Salles. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Sebastien Salles, Laboratory of biomedical imaging - CNRS, Paris, France

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.