AUTHOR=Pleyer Jonas , Fleck Christian 

TITLE=Agent-based models in cellular systems

JOURNAL=Frontiers in Physics

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2022.968409

DOI=10.3389/fphy.2022.968409

ISSN=2296-424X

ABSTRACT=<p>This mini-review discusses agent-based models as modeling techniques for studying pattern formation of multi-cellular systems in biology. We introduce and compare different agent-based model frameworks with respect to spatial representation, microenvironment, intracellular and extracellular reactions, cellular properties, implementation, and practical use. The guiding criteria for the considered selection of agent-based model frameworks are that they are actively maintained, well documented, and provide a model development workflow.</p>