AUTHOR=Wu Ji , Tang Ju , Zhang Jiawei , Di Jianglei TITLE=Coherent noise suppression in digital holographic microscopy based on label-free deep learning JOURNAL=Frontiers in Physics VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2022.880403 DOI=10.3389/fphy.2022.880403 ISSN=2296-424X ABSTRACT=

Deep learning techniques can be introduced into the digital holography to suppress the coherent noise. It is often necessary to first make a dataset of noisy and noise-free phase images to train the network. However, noise-free images are often difficult to obtain in practical holographic applications. Here we propose a label-free training algorithms based on self-supervised learning. A dilated blind spot network is built to learn from the real noisy phase images and a noise level function network to estimate a noise level function. Then they are trained together via maximizing the constrained negative log-likelihood and Bayes’ rule to generate a denoising phase image. The experimental results demonstrate that our method outperforms standard smoothing algorithms in accurately reconstructing the true phase image in digital holographic microscopy.