AUTHOR=Heslin Caitlin , Boehm Daniela , Gilmore Brendan F. , Megaw Julianne , Freeman Theresa A. , Hickok Noreen J. , Cullen P. J. , Bourke Paula TITLE=Biomolecules as Model Indicators of In Vitro and In Vivo Cold Plasma Safety JOURNAL=Frontiers in Physics VOLUME=8 YEAR=2021 URL=https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2020.613046 DOI=10.3389/fphy.2020.613046 ISSN=2296-424X ABSTRACT=
The potential applications for cold plasma in medicine are extensive, from microbial inactivation and induction of apoptosis in cancer cells to stimulating wound healing and enhancing the blood coagulation cascade. The safe bio-medical application of cold plasma and subsequent effect on complex biological pathways requires precision and a distinct understanding of how physiological redox chemistry is manipulated. Chemical modification of biomolecules such as carbohydrates, proteins, and lipids treated with cold plasma have been characterized, however, the context of how alterations of these molecules affect cell behavior or