AUTHOR=Stasica Paulina , Baran Jakub , Granja Carlos , Krah Nils , Korcyl Grzegorz , Oancea Cristina , Pawlik-Niedźwiecka Monika , Niedźwiecki Szymon , Rydygier Marzena , Schiavi Angelo , Rucinski Antoni , Gajewski Jan 

TITLE=A Simple Approach for Experimental Characterization and Validation of Proton Pencil Beam Profiles

JOURNAL=Frontiers in Physics

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2020.00346

DOI=10.3389/fphy.2020.00346

ISSN=2296-424X

ABSTRACT=<p>A precise characterization of therapeutic proton pencil beams is essential for the commissioning of any treatment planning system (TPS). The dose profile characterization includes measurement of the beam lateral dose profile in the beam core and far from the beam core, in the so called low-dose envelope, and requires a sophisticated detection system with a few orders of magnitude dynamic range. We propose the use of a single-quantum-sensitive M<sc>ini</sc>P<sc>ix</sc> T<sc>imepix</sc> detector, along with an in-house-designed holder to perform measurements of the pencil beam dose profile in air and in water. We validated the manufacturer calibration of the M<sc>ini</sc>P<sc>ix</sc> T<sc>imepix</sc> detector in proton beams of various energies and compared the deposited energy spectra to Monte Carlo (MC) simulations. The precision of the lateral dose profile measurements has been systematically validated against Krakow proton facility commissioning data and dose profile simulations performed with MC codes Gate/Geant4 and Fred. We obtained an excellent agreement between M<sc>ini</sc>P<sc>ix</sc> T<sc>imepix</sc> measurements and simulations demonstrating the feasibility of the system for a simple characterization and validation of proton pencil beams. The proposed approach can be implemented at any proton therapy facility to acquire experimental data needed to commission and validate analytical and MC-based TPS.</p>