AUTHOR=Winter Gordon , Koch Andrea B. F. , Löffler Jessica , Jelezko Fedor , Lindén Mika , Li Hao , Abaei Alireza , Zuo Zhi , Beer Ambros J. , Rasche Volker 

TITLE=In vivo PET/MRI Imaging of the Chorioallantoic Membrane

JOURNAL=Frontiers in Physics

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2020.00151

DOI=10.3389/fphy.2020.00151

ISSN=2296-424X

ABSTRACT=<p>The Hen's Egg Test Chorioallantoic Membrane (HET-CAM) of fertilized chick eggs represents a unique model for biomedical research. With its steadily increasing use, non-invasive <italic>in ovo</italic> imaging for longitudinal direct quantification of the biodistribution of compounds or monitoring of surrogate markers has been introduced. The full range of imaging methods has been applied to the HET-CAM model. From the current perspective, Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) appear promising techniques, providing detailed anatomical and functional information (MRI) and excellent sensitivity (PET). Especially by combining both techniques, the required sensitivity and anatomical localization of the signal source renders feasible. In the following, a review of recent applications of MRI and PET for <italic>in ovo</italic> imaging with a special focus on techniques for imaging <italic>xenotransplanted</italic> tumors on the CAM will be provided.</p>