AUTHOR=Nyayapathi Nikhila , Zheng Emily , Zhou Qifa , Doyley Marvin , Xia Jun TITLE=Dual-modal photoacoustic and ultrasound imaging: from preclinical to clinical applications JOURNAL=Frontiers in Photonics VOLUME=5 YEAR=2024 URL=https://www.frontiersin.org/journals/photonics/articles/10.3389/fphot.2024.1359784 DOI=10.3389/fphot.2024.1359784 ISSN=2673-6853 ABSTRACT=

Photoacoustic imaging is a novel biomedical imaging modality that has emerged over the recent decades. Due to the conversion of optical energy into the acoustic wave, photoacoustic imaging offers high-resolution imaging in depth beyond the optical diffusion limit. Photoacoustic imaging is frequently used in conjunction with ultrasound as a hybrid modality. The combination enables the acquisition of both optical and acoustic contrasts of tissue, providing functional, structural, molecular, and vascular information within the same field of view. In this review, we first described the principles of various photoacoustic and ultrasound imaging techniques and then classified the dual-modal imaging systems based on their preclinical and clinical imaging applications. The advantages of dual-modal imaging were thoroughly analyzed. Finally, the review ends with a critical discussion of existing developments and a look toward the future.