Frontiers in Pharmacology

Original Research

Accepted on 16 Apr 2025

IGFBP5 mediates the therapeutic effect of isoliquiritigenin in myocardial ischemia-reperfusion injury via AKT/GLUT4 regulated insulin resistance

in Cardiovascular and Smooth Muscle Pharmacology

Jue Bai
Si-Yuan Yang
Shao-Mei Yu
Ying Cao
Xuan-Yi Hu
Xiong Chen
Ying-Nan Song
Hongjin Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544869

Original Research

Published on 16 Apr 2025

Multi - dimensional mechanism analysis of Choerospondias axillaris (Roxb.) Burtt et Hill in treating kidney stones: network pharmacology, molecular docking and in vitro experimental verification

in Renal Pharmacology

Meiqi Qiu
Senhua Li
Yu Zhang
Jiaoxia Yan
Shiting Qin
Xijing Yin
Yujun Li
Chunhui Zeng
Ke Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1501386

355 views

Original Research

Published on 16 Apr 2025

Repurposing major metabolites of lamiaceae family as potential inhibitors of α-synuclein aggregation to alleviate neurodegenerative diseases: an in silico approach

in Experimental Pharmacology and Drug Discovery

Soham Bhattacharya
Neha Gupta
Adrish Dutta
Pijush Kanti Khanra
Ritesh Dutta
Jana Žiarovská
Nikolay T. Tzvetkov
Lucie Severová
Lenka Kopecká
Luigi Milella

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519145

366 views

Original Research

Published on 16 Apr 2025

Honeysuckle extracts as a potential inhibitor of SARS-CoV-2 infection

in Ethnopharmacology

Ping-Chang Lin
Ying-Ray Lee
Li-Teh Liu
Shyh-Shin Chiou
Po-Chih Chen
Ching-Yi Tsai
Jih-Jin Tsai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1517585

286 views

Review

Published on 16 Apr 2025

A crucial role of miR-155 in the pathomechanism of acute kidney injury

in Renal Pharmacology

Hui Wang
Jian Liao
Wei Wang
Jianhua Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1570000

250 views

Review

Published on 16 Apr 2025

SREBP2 as a central player in cancer progression: potential for targeted therapeutics

in Pharmacology of Anti-Cancer Drugs

Ruiqi Chen
Tianyu Chen
Xiang Li
Junfeng Yu
Min Lin
Siqi Wen
Man Zhang
Jinchi Chen
Bei Yi
Huage Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1535691

259 views

Original Research

Published on 16 Apr 2025

SUMOylation substrate encoding genes as prognostic biomarkers in pancreatic ductal adenocarcinoma with functional assessment of SAF-B2

in Pharmacology of Anti-Cancer Drugs

Xiangjun Wang
Chuanxin Yang
Yangming Liu
Jian Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1532658

243 views

Original Research

Published on 16 Apr 2025

Synthesis of a novel mitochondrial fluorescent probe - killing cancer cells in vitro and in vivo

in Pharmacology of Anti-Cancer Drugs

Xiaowen Yang
Yiting Zhan
Yifei Li
Xinzhuang Shen
Yuqiu Ma
Zongjun Liu
Yipeng Liu
Chengjin Liang
Xiaoyuan Zhang
Yehao Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543559

300 views

Original Research

Published on 16 Apr 2025

Gui-zhi-fu-ling-wan alleviates bleomycin-induced pulmonary fibrosis through inhibiting epithelial-mesenchymal transition and ferroptosis

in Ethnopharmacology

Zi-Yong Chen
Meng-Meng Ma
Rui Wang
Qing-Qing Zhang
Mei-Ling Xie
Ying-Li Wang
Yong-Xia Guo
Kui Liu
Li-Fang Cao
Feng-Lian He

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1552251

345 views

Review

Published on 16 Apr 2025

Hepatorenal protective effects of essential oils against chemical overexposure induced oxidative damage

in Experimental Pharmacology and Drug Discovery

Faming Jiang
Xiaoyan Huang
Xingying Chen
Yuanhua Xian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580805

270 views

Systematic Review

Published on 16 Apr 2025

Scoping review of ethnobotanical studies on Piliostigma thonningii (Schumach.) Milne-Redh. in Sub-Saharan Africa

in Ethnopharmacology

Bono Nethathe
Lonia Maanea Ramphinwa
Ananias Selekane Motadi
Frans Koketso Matlakala

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575548

257 views

Original Research

Published on 16 Apr 2025

The development of a high-throughput acoustic droplet ejection mass-spectrometry assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of SLC1-A3, -A2 and -A1 in a drug discovery program

in Experimental Pharmacology and Drug Discovery

Yasmin Zuschlag
Antje Pommereau
Jennifer Warkentin
Thomas Licher
Felix Bärenz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544682

378 views

Original Research

Published on 16 Apr 2025

Dracaena trifasciata (Prain) Mabb leaf extract protects MIN6 pancreas-derived beta cells against the diabetic toxin streptozotocin: role of the NF-κB pathway

in Ethnopharmacology

Christiaan Warner Hoornenborg
Nur Qomariyah
Herson Antonio González-Ponce
André Petrus Van Beek
Han Moshage
Gertjan Van Dijk

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1485952

591 views

Review

Published on 16 Apr 2025

Emerging roles of exosomes in the diagnosis and treatment of kidney diseases

in Renal Pharmacology

Huanhuan Cao
Zixi Li
Jiajia Ye
Yi Lv
Chun Zhang
Tao Liang
Yumei Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1525314

215 views

Original Research

Published on 16 Apr 2025

Association of long-term use of dipeptidyl peptidase-4 inhibitors with the risk of diabetic retinopathy in patients with diabetes mellitus: a real-world evidence study

in Pharmacoepidemiology

Yu-Ching Li
Yu-Hsiang Kuan
Yih Yang
Shuo-Yan Gau
Kun-Yu Su
Tung-Han Tsai
Kuang-Hua Huang
Chien-Ying Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1518545

353 views

Editorial

Published on 16 Apr 2025

Editorial: Multi-omics application in exploring potential biomarkers targeting resistance of anti-cancer drugs

in Pharmacology of Anti-Cancer Drugs

Huan Wang
Jindong Xie
Zhi Tian
Diane S. Allen-Gipson
Hailin Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594064

306 views