Frontiers in Pharmacology

Original Research

Published on 23 Jan 2025

Trazodone effectiveness in depression: impacts of trazodone extended release vs SSRIs on the health status and quality of life of patients with major depressive disorder

in Neuropharmacology

Marcin Siwek
Adrian Andrzej Chrobak
Anna Julia Krupa
Aleksandra Gorostowicz
Andrzej Juryk
Dominika Dudek

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1525498

572 views

Mini Review

Published on 23 Jan 2025

A ketogenic diet regulates microglial activation to treat drug addiction

in Neuropharmacology

Jie Ji
Yi Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1462699

933 views

Original Research

Published on 23 Jan 2025

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

in Pharmacology of Anti-Cancer Drugs

Shunqiao Jin
Xiaojiao Liu
Lingqin Cai
Jiayu Yan
Ling Li
Hongjun Dong
Yuxue Gao
Xicong Zhu
Cong Zhang
Xuezhu Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545243

517 views

Review

Published on 23 Jan 2025

A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms

in Experimental Pharmacology and Drug Discovery

Yuan Yan
Yiyao Wu
Yu Zhao
Yaguang Yang
Guangtao An
Zhidong Liu
Dongli Qi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1513406

580 views

Clinical Trial

Published on 23 Jan 2025

Comparison of a ready-to-use intranasal dexmedetomidine spray with traditional intranasal dexmedetomidine drops for sedation in preschool children: a prospective, randomized, controlled study

in Obstetric and Pediatric Pharmacology

Qi-Qi Jin
Wei-Cha Cai
Ying-Feng Zhou
Yan-Tong Zhang
Gang Chen
Meng-Ting Xu
Jun Li
Kai-Ming Yuan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1528612

441 views

Original Research

Published on 23 Jan 2025

Modified citrus pectin ameliorates methotrexate-induced hepatic and pulmonary toxicity: role of Nrf2, galectin-3/TLR-4/NF-κB/TNF-α and TGF-β signaling pathways

in Pharmacology of Anti-Cancer Drugs

Randa Ismail
Heba A. Habib
Aliaa F. Anter
Amr Amin
Gehan H. Heeba

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1528978

845 views

Original Research

Published on 23 Jan 2025

Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: implications for the involvement of pirin

in Pharmacology of Anti-Cancer Drugs

Bardees M. Foda
Annika E. Baker
Łukasz Joachimiak
Marzena Mazur
Richard R. Neubig

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1505000

465 views

Systematic Review

Published on 23 Jan 2025

Comparative efficacy and safety of 20 intravenous pharmaceutical intervention for prevention of etomidate-induced myoclonus: a systematic review and Bayesian network meta-analysis

in Drugs Outcomes Research and Policies

Lu Chen
Pengxiang Zhou
Zhengqian Li
Ziyang Wu
Suodi Zhai

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1507616

504 views

Original Research

Published on 23 Jan 2025

Integrated serum metabolomics and network pharmacology reveal molecular mechanism of Qixue Huazheng formula on peritoneal fibrosis

in Renal Pharmacology

Xiaohui Meng
Li Sheng
Yongqing You
Huibo Dai
Manshu Yu
Funing Wang
Ziren Zhou
Yun Shan
Meixiao Sheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1515038

543 views

Systematic Review

Published on 23 Jan 2025

Fosaprepitant as combination therapy to prevent chemotherapy-induced vomiting in children: a meta-analysis

in Obstetric and Pediatric Pharmacology

Yanshuo Shi
Yuanyuan Yue
Yue Zhang
Guoxun Pang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1509928

448 views

Original Research

Published on 22 Jan 2025

Development and pan-cancer validation of an epigenetics-based random survival forest model for prognosis prediction and drug response in OS

in Pharmacology of Anti-Cancer Drugs

Chaoyi Yin
Kede Chi
Zhiqing Chen
Shabin Zhuang
Yongsheng Ye
Binshan Zhang
Cailiang Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1529525

489 views

Original Research

Published on 22 Jan 2025

Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice

in Neuropharmacology

Mansi Dahalia
Sparsh Gupta
Haya Majid
Divya Vohora
Nidhi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1528032

875 views

Original Research

Published on 22 Jan 2025

Efferocytosis-related gene IL33 predicts prognosis and immune response and mediates proliferation and migration in vitro and in vivo of breast cancer

in Pharmacology of Anti-Cancer Drugs

Xiao He
Xianjie Cheng
Zhun Zhang
Lanhui Chen
Changjun Xie
Mengjie Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533571

600 views

Original Research

Published on 22 Jan 2025

Drivers of innovation value: simulation for new drug pricing evaluation based on system dynamics modelling

in Drugs Outcomes Research and Policies

Qian Xing
Wendi Cheng
Wei Wang
Chunlin Jin
Haiyin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1474856

564 views

Mini Review

Published on 22 Jan 2025

Brief summary of the regulatory frameworks of regenerative medicine therapies

in Translational Pharmacology

Jinah Yoon
Sukhyang Lee
Min Jung Kim
Jung-Hyun Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486812

628 views

Original Research

Published on 22 Jan 2025

Better understanding the phenotypic effects of drugs through shared targets in genetic disease networks

in Pharmacogenetics and Pharmacogenomics

Elena Díaz-Santiago
Aurelio A. Moya-García
Jesús Pérez-García
Raquel Yahyaoui
Christine Orengo
Florencio Pazos
James R. Perkins
Juan A. G. Ranea

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1470931

637 views

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Articles

Trazodone effectiveness in depression: impacts of trazodone extended release vs SSRIs on the health status and quality of life of patients with major depressive disorder

A ketogenic diet regulates microglial activation to treat drug addiction

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms

Comparison of a ready-to-use intranasal dexmedetomidine spray with traditional intranasal dexmedetomidine drops for sedation in preschool children: a prospective, randomized, controlled study

Modified citrus pectin ameliorates methotrexate-induced hepatic and pulmonary toxicity: role of Nrf2, galectin-3/TLR-4/NF-κB/TNF-α and TGF-β signaling pathways

Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: implications for the involvement of pirin

Comparative efficacy and safety of 20 intravenous pharmaceutical intervention for prevention of etomidate-induced myoclonus: a systematic review and Bayesian network meta-analysis

Integrated serum metabolomics and network pharmacology reveal molecular mechanism of Qixue Huazheng formula on peritoneal fibrosis

Fosaprepitant as combination therapy to prevent chemotherapy-induced vomiting in children: a meta-analysis

Development and pan-cancer validation of an epigenetics-based random survival forest model for prognosis prediction and drug response in OS

Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice

Efferocytosis-related gene IL33 predicts prognosis and immune response and mediates proliferation and migration in vitro and in vivo of breast cancer

Drivers of innovation value: simulation for new drug pricing evaluation based on system dynamics modelling

Brief summary of the regulatory frameworks of regenerative medicine therapies

Better understanding the phenotypic effects of drugs through shared targets in genetic disease networks