Frontiers in Pharmacology

Original Research

Accepted on 13 Feb 2025

Signal Detection and Safety Analysis of Three Tyrosine Kinase Inhibitors for HER-2 Positive Breast Cancer: A Retrospective Study Based on the FAERS Database

in Pharmacoepidemiology

Xiting Tang
ChengLiang Wang
Yanwei Li
Jing Tang
Guoping Zhang
Li Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538881

Review

Accepted on 13 Feb 2025

The Multiple Biological Activities of Hyperoside: From Molecular Mechanisms to Therapeutic Perspectives in Neoplastic and Non-Neoplastic Diseases

in Pharmacology of Anti-Cancer Drugs

Weisong Zhang
Wang Rui
Rongqi Guo
ZhongQuan Yi
Yihao Wang
Hao Wang
Yangyang Li
Xia Li
Jianxiang Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538601

Original Research

Accepted on 13 Feb 2025

Paeonia suffruticosa Andrews Root Extract Ameliorates Photoaging via Regulating IRS1/PI3K/FOXO Pathway

in Ethnopharmacology

Junxi Liu
Youyun Liu
Feifei Wang
Yonglei Yuan
Hongyu Ma
Liping Qu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1520392

Original Research

Accepted on 13 Feb 2025

Gut Microbiota-Derived Metabolite Phenylacetylglutamine Inhibits the Progression of Prostate Cancer by Suppressing the Wnt/β-Catenin Signaling Pathway

in Pharmacology of Anti-Cancer Drugs

Jing Lv
Shengkai Jin
Yuhua Zhou
Chaowei Fu
Yang Shen
Bo Liu
Jufa Li
Menglu Li
Yuwei Zhang
Ninghan Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1528058

Original Research

Accepted on 13 Feb 2025

Efficient substructure feature encoding based on graph neural network blocks for drug-target interaction prediction

in Experimental Pharmacology and Drug Discovery

Guojian Deng
Changsheng Shi
Ruiquan Ge
Riqian Hu
Changmiao Wang
Feiwei Qin
Cheng Pan
Haixia Mao
Qing Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1553743

Original Research

Published on 13 Feb 2025

Network analysis and experimental validation to investigate chenpi against functional dyspepsia through TLR4/MyD88 by regulating the gut microbial structure

in Ethnopharmacology

Jinfang Hu
Xu Wang
Xiaoqiu Guo
Wen Wen
Jin Xue
Zhengzheng Liao
Lihua Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1495799

227 views

Review

Published on 13 Feb 2025

The role and application of bioinformatics techniques and tools in drug discovery

in Experimental Pharmacology and Drug Discovery

Shujun Zhang
Kaijie Liu
Yafeng Liu
Xinjun Hu
Xinyu Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547131

239 views

Review

Published on 13 Feb 2025

Recent development of mitochondrial metabolism and dysfunction in osteoarthritis

in Experimental Pharmacology and Drug Discovery

Pengchao Guo
Ahmad Alhaskawi
Safwat Adel Abdo Moqbel
Zhijun Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538662

172 views

Original Research

Published on 13 Feb 2025

Saliva-derived components can enhance the performance of toluidine blue in photodynamic therapy

in Experimental Pharmacology and Drug Discovery

Nicolas Macri
Luana Mendonça Dias
Ana Claudia Pavarina
Walter L. Siqueira
Felipe Fornias Sperandio

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538520

178 views

Original Research

Published on 13 Feb 2025

Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways

in Predictive Toxicology

Qingshan Tang
Jiachen Dong
Feng Zhang
Dan Zhao
Qi Yang
Jiayu Wen
Yuhao Sun
Jifu Wei
Zhixian Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1489210

231 views

Original Research

Published on 13 Feb 2025

Time in the therapeutic range, bleeding event, and their determinants in older patients with atrial fibrillation on warfarin in Ethiopia: multicenter cross-sectional study

in Drugs Outcomes Research and Policies

Zenaw Debasu Addisu
Desalegn Getnet Demsie
Chernet Tafere
Taklo Simeneh Yazie
Destaw Endeshaw
Bereket Bahiru Tefera
Malede Berihun
Dessale Abate Beyene

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541592

188 views

Original Research

Published on 13 Feb 2025

Real-world pharmacovigilance investigation of imipenem/cilastatin: signal detection using the FDA Adverse Event Reporting System (FAERS) database

in Pharmacoepidemiology

Peng Jia
Yusen Zhou
Yuan Gao
Shangyu Wang
Jiangliu Yin
Yixiang Lian
Quanyou Lai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524159

157 views

Review

Published on 13 Feb 2025

Exploring the application of metal-based photothermal agents in photothermal therapy combined with immune checkpoint therapy

in Translational Pharmacology

Bin Xie
ZhiRong Xiao
JiaBao Ling
Yichao Peng
Tianfeng Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1553158

152 views

Original Research

Published on 13 Feb 2025

Exploring skin adverse events and mechanisms of apalutamide using data mining algorithms and network pharmacology

in Pharmacology of Anti-Cancer Drugs

Yaqing Chen
Longzhuan Huang
Wenwei Li
Hangye Gu
Yong Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1517874

161 views

Original Research

Published on 13 Feb 2025

Development of a phenotypic screening assay to measure activation of cancer-associated fibroblasts

in Experimental Pharmacology and Drug Discovery

Marcus M. Ilg
Alice R. Lapthorn
Sophie L. Harding
Tariq Minhas
Gouri Koduri
Stephen A. Bustin
Selim Cellek

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526495

353 views

Original Research

Published on 13 Feb 2025

Novel human single-domain antibodies exert potent anti-tumor activity by targeting EGF-like repeat epitope of EpCAM

in Experimental Pharmacology and Drug Discovery

Xiaofeng Zhou
Zhifang Liu
Weixiong Zhang
Lin Dai
Tao Chen
Zexiong Lin
Hong Pan
Qi Qi
Henry Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1530268

195 views

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Articles

Signal Detection and Safety Analysis of Three Tyrosine Kinase Inhibitors for HER-2 Positive Breast Cancer: A Retrospective Study Based on the FAERS Database

The Multiple Biological Activities of Hyperoside: From Molecular Mechanisms to Therapeutic Perspectives in Neoplastic and Non-Neoplastic Diseases

Paeonia suffruticosa Andrews Root Extract Ameliorates Photoaging via Regulating IRS1/PI3K/FOXO Pathway

Gut Microbiota-Derived Metabolite Phenylacetylglutamine Inhibits the Progression of Prostate Cancer by Suppressing the Wnt/β-Catenin Signaling Pathway

Efficient substructure feature encoding based on graph neural network blocks for drug-target interaction prediction

Network analysis and experimental validation to investigate chenpi against functional dyspepsia through TLR4/MyD88 by regulating the gut microbial structure

The role and application of bioinformatics techniques and tools in drug discovery

Recent development of mitochondrial metabolism and dysfunction in osteoarthritis

Saliva-derived components can enhance the performance of toluidine blue in photodynamic therapy

Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways

Time in the therapeutic range, bleeding event, and their determinants in older patients with atrial fibrillation on warfarin in Ethiopia: multicenter cross-sectional study

Real-world pharmacovigilance investigation of imipenem/cilastatin: signal detection using the FDA Adverse Event Reporting System (FAERS) database

Exploring the application of metal-based photothermal agents in photothermal therapy combined with immune checkpoint therapy

Exploring skin adverse events and mechanisms of apalutamide using data mining algorithms and network pharmacology

Development of a phenotypic screening assay to measure activation of cancer-associated fibroblasts

Novel human single-domain antibodies exert potent anti-tumor activity by targeting EGF-like repeat epitope of EpCAM