ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Neuropharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1599641
This article is part of the Research TopicResearch on Precision Prevention and Treatment of Neurological and Neurodegenerative DiseasesView all 4 articles
Association of Serum Insulin-like Growth Factor-1 and Adrenocorticotropic Hormone Therapeutic Response in Patients with Infantile Epileptic Spasms Syndrome
Provisionally accepted
- 1Department of Neurology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- 2Clinical Research Ward, Clinical Research Center, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- 3Department of Pharmacy, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- 4Department of Neurology, Shanghai Children’s Medical Center, Hainan Branch, Shanghai Jiao Tong University School of Medicine, Sanya, China
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Infantile epileptic spasm syndrome (IESS), a rare age-specific epileptic encephalopathy, exhibits limited therapeutic efficacy, with approximately 50% of patients showing resistance to adrenocorticotropic hormone (ACTH) monotherapy. Herein, we investigated the association between serum insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3), their ratio, and short-term ACTH therapeutic response in IESS, alongside their correlation with video-electroencephalogram (VEEG) characteristics.
Keywords: insulin-like growth factor-1, Insulin-like growth factor-binding protein-3, Adrenocorticotropic Hormone, Infantile epileptic spasms syndrome, Video-electroencephalogram, rare disease
Received: 25 Mar 2025; Accepted: 21 Apr 2025.
Copyright: © 2025 Lin, Han, Wang, Zhao, Wang, Li and ZHOU. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hao Li, Department of Neurology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
YUNQING ZHOU, Department of Neurology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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