AUTHOR=Correia Cristina , Ung Choong-Yong , Li Hu , Costello James C. TITLE=Editorial: State‐of‐the‐art hypothesis-driven systems pharmacology and artificial intelligence approaches to decipher disease complexity JOURNAL=Frontiers in Pharmacology VOLUME=16 YEAR=2025 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1593164 DOI=10.3389/fphar.2025.1593164 ISSN=1663-9812