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Angela Roco1,2,3Elena Nieto4Marcelo Suárez1Mario Rojo1,5Maria Paz Bertoglia6Gabriel Verón1Francisca Tamayo1Annabella Arredondo7Daniela Cruz4Jessica Muñoz4Gabriela Bravo8Patricio Salas9Fanny Mejías10Gerald Godoy10Paulo Véliz10
Luis Abel Quiñones1,5*- 1Laboratory of Chemical Carcinogenesis and Pharmacogenetics, Department of Basic and Clinical Oncology, Faculty of Medicine, University of Chile, Santiago, Chile
- 2Escuela de Bioquímica Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile
- 3Western Metropolitan Health Service, Santiago, Chile
- 4San Juan de Dios Hospital, Santiago, Chile
- 5Latin American Network for Implementation and Validation of Clinical Pharmacogenomics Guidelines (RELIVAF-CYTED), Madrid, Spain
- 6Institute of Population Health, University of Chile, Santiago, Chile
- 7Instituto de Salud Pública, Universidad Andrés Bello, Santiago, Chile
- 8Curacaví Hospital, Curacaví, Chile
- 9Dr. Salvador Allende G. Reference Health Center, Santiago, Chile
- 10San José de Melipilla Hospital, Melipilla, Chile
A Corrigendum on
A pharmacogenetically-guided acenocoumarol dosing algorithm for Chilean patients: a discovery cohort study
by Roco A, Nieto E, Suárez M, Rojo M, Bertoglia MP, Verón G, Tamayo F, Arredondo A, Cruz D, Muñoz J, Bravo G, Salas P, Mejías F, Godoy G, Véliz P and Quiñones LA (2020). Front. Pharmacol. 11:325. doi: 10.3389/fphar.2020.00325
In the published article, there was an error in Figure 1 as published. The patient numbers are listed as 377 --> 377 --> 304, but it should say 377 --> 305 --> 304. The corrected Figure 1 and its caption appear below.
Figure 1
Figure 1. Patient recruitment and selection flowchart.
In the published article, there was an error in Results, Algorithm for Acenocoumarol Dosing in the Chilean Population. In the formula two factors have decimals placed incorrectly. It’s a formatting error, but it is significant as it impacts the dose calculations.
The formula previously stated:
“Log WTD = 3.081 + (0.167 × men) - (age × 0.081) - (initial INR × 0.55) + (BMI × 0.013) - (CYP2C9*1/*2 × 0.107) - (CYP2C9*1/*3 × 0.323) - (CYP2C9*3/*3 × 0.746) - (VKORC1 G/A × 0.270) - (VKORC1 A/A × 0.701).”
The corrected formula appears below:
“Log WTD = 3.081 + (0.167 × men) - (age × 0.0081) - (initial INR × 0.055) + (BMI × 0.013) - (CYP2C9*1/*2 × 0.107) - (CYP2C9*1/*3 × 0.323) - (CYP2C9*3/*3 × 0.746) - (VKORC1 G/A × 0.270) - (VKORC1 A/A × 0.701).”
In the published article, there was an error in Results, Genotype Distribution in the Study Population, paragraph 1.
This sentence previously stated:
“The analysis of the HWE showed that only CYP2C9*3 (rs1057910) is in HWE (chi2 = 4.67). All other SNPs, VKORC1 (rs9923231) (chi2 = 0.09), VKORC1 (rs7294) (chi2 = 0.62), GGCx (rs11676382) (chi2 = 1.2), CYP4F2 (rs2108622) (chi2 = 1.02), ApoE (rs429358) (chi2 = 0.08), ABCB1 (rs1045642) (chi2 = 0.68), and CYP2C9*2 (rs1799853) (chi2 = 2.33), are not in HWE.”
The corrected sentence appears below:
“The analysis of the HWE showed that only CYP2C9*3 (rs1057910) is not in HWE (chi2 = 4.67). All other SNPs, VKORC1(rs9923231) (chi2 = 0.09), VKORC1 (rs7294) (chi2 = 0.62), GGCx (rs11676382) (chi2 = 1.2), CYP4F2 (rs2108622) (chi2 = 1.02), ApoE (rs429358) (chi2 = 0.08), ABCB1 (rs1045642) (chi2 = 0.68), and CYP2C9*2 (rs1799853) (chi2 = 2.33), are in HWE.”
The correspondence email for author Luis Abel Quiñones has been updated in the published article to bHF1aW5vbmVAdWNoaWxlLmNs.
The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: acenocoumarol, coumarins, algorithm, pharmacogenetics, pharmacogenomics, anticoagulation
Citation: Roco A, Nieto E, Suárez M, Rojo M, Bertoglia MP, Verón G, Tamayo F, Arredondo A, Cruz D, Muñoz J, Bravo G, Salas P, Mejías F, Godoy G, Véliz P and Quiñones LA (2025) Corrigendum: A pharmacogenetically-guided acenocoumarol dosing algorithm for Chilean patients: a discovery cohort study. Front. Pharmacol. 16:1588440. doi: 10.3389/fphar.2025.1588440
Received: 05 March 2025; Accepted: 13 March 2025;
Published: 31 March 2025.
Edited and reviewed by:
Nathalie K. Zgheib, American University of Beirut, LebanonCopyright © 2025 Roco, Nieto, Suárez, Rojo, Bertoglia, Verón, Tamayo, Arredondo, Cruz, Muñoz, Bravo, Salas, Mejías, Godoy, Véliz and Quiñones. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Luis Abel Quiñones, bHF1aW5vbmVAdWNoaWxlLmNs