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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Integrative and Regenerative Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1587890
This article is part of the Research TopicInnovative Approaches for Wound TreatmentView all 10 articles
Multifunctional PdH-Hydride MOFs for Synergistic Hydrogen and Photothermal Antibacterial Therapy in Accelerated Wound Healing
Provisionally accepted- 1Shandong Second Medical University, Weifang, Shandong Province, China
- 2Weifang People's Hospital, Weifang, China
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The escalating threat of bacterial infections poses a serious challenge to public health, highlighting the urgent demand for innovative antibacterial agents and therapeutic strategies. In response to this need, we have developed a multifunctional nanoplatform based on Palladium-Hydrogen (PdH)-hydride metal-organic frameworks (MOFs), designated as PdH@ZIF@PDA/Ag nanoparticles (abbreviated as P(H)ZPAg NPs). This system integrates PdH encapsulation within a zeolitic imidazolate framework (ZIF-8), polydopamine (PDA) surface modification, and in situ generation of silver nanoparticles (Ag NPs) to achieve a synergistic antibacterial effect. The P(H)ZPAg nanoplatform was systematically characterized for its hydrogen release capability, photothermal therapy (PTT), and Ag-mediated bactericidal activity. In vitro studies revealed that P(H)ZPAg NPs exhibited potent synergistic antibacterial efficacy against both Escherichia coli and Staphylococcus aureus. Furthermore, in a Staphylococcus aureus-infected rat wound model, P(H)ZPAg NPs significantly accelerated wound closure and enhanced bacterial eradication compared to controls. These results confirm that the combination of hydrogen therapy, PTT, and silver ion release within a single nanoplatform can markedly improve antibacterial outcomes. Overall, this study presents a novel strategy for designing multifunctional antibacterial nanoplatforms, offering a promising approach for the effective treatment of topical bacterial infections wound care.
Keywords: antibacterial therapy, hydrogen therapy, photothermal therapy, Wound Healing, hydride MOFs
Received: 05 Mar 2025; Accepted: 11 Apr 2025.
Copyright: © 2025 Wang, Zhang, Qi, Huang, Ding and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chuanliang Liu, Weifang People's Hospital, Weifang, China
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