REVIEW article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1587314
This article is part of the Research TopicAdvances in Bioactive Compounds: Mechanisms and Therapeutic PotentialsView all 4 articles
Quercetin as a Therapeutic Agent for Acute Pancreatitis: A Comprehensive Review of Antioxidant, Anti-inflammatory, and Immunomodulatory Mechanisms
Provisionally accepted
- 1Zhejiang Chinese Medical University, Hangzhou, China
- 2First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China
- 3Hospital of Azha Town, Jiali County, Naqu City, Xizang Autonomous Region, China
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Acute pancreatitis (AP) is a severe inflammatory disorder of the pancreas, characterized by high morbidity and mortality rates. Despite significant advancements in understanding the pathophysiological mechanisms of AP, current treatment options still face considerable limitations. Recent studies have underscored the therapeutic potential of quercetin, a natural flavonoid, due to its potent antioxidant, anti-inflammatory, and immunomodulatory properties, positioning it as a promising therapeutic candidate for AP. This review explores the effects of quercetin on AP, highlighting its antioxidant activities, its role in immune modulation, and its protective effects on pancreatic tissue. Furthermore, it examines quercetin's multi-target mechanisms and its advantages over conventional therapies, such as N-acetylcysteine and corticosteroids. Although preliminary studies suggest that quercetin can alleviate inflammation and oxidative stress in AP, clinical evidence remains limited. One of the main challenges for quercetin's clinical application is its low bioavailability. Future research should focus on strategies to enhance its bioavailability and on conducting large-scale randomized controlled trials to more comprehensively assess its efficacy and safety in the treatment of AP.
Keywords: Quercetin, acute pancreatitis, antioxidant, anti-inflammatory, immunomodulatory, bioavailability
Received: 04 Mar 2025; Accepted: 21 Apr 2025.
Copyright: © 2025 Jiang, Lhamo, Ma, Ye, Chen, He, Xu and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jin Chen, Zhejiang Chinese Medical University, Hangzhou, China
Yibo He, First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310003, Zhejiang Province, China
Jian Xu, Zhejiang Chinese Medical University, Hangzhou, China
Liquan Huang, First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310003, Zhejiang Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.