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ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1583635
Investigating the Regulation of the miR-199a-3p/TGF-β/Smad Signaling Pathway by BSHXF Drug-Containing Serum Combined with ADSCs for Delaying Intervertebral Disc Degeneration
Provisionally accepted- Hunan University of TCM, Chang sha,Hunan, China
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Background: Intervertebral disc degeneration (IDD) significantly contributes to low back pain (LBP), yet effective treatment options are scarce. BSHXF, a classical traditional Chinese medicine formula, demonstrates dual pharmacological actions: tonifying kidneys, strengthening bones, activating blood circulation, and resolving stasis. It has been widely used in IDD management. Given its potential, combining BSHXF with miRNA regulation and stem cell therapy may enhance therapeutic outcomes by targeting molecular and cellular pathways underlying IDD pathogenesis.
Keywords: Intervertebral Disc Degeneration, miR-199a-3p/TGF-β/Smad signaling pathway, adipose-derived stem cells, Oxidative Stress, Extracellular matrix synthesis
Received: 26 Feb 2025; Accepted: 14 Apr 2025.
Copyright: © 2025 Liu, Sun, Yang, Jiang, Sun, Chen, Jiahao and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Enxu Liu, Hunan University of TCM, Chang sha,Hunan, China
Duan Jiahao, Hunan University of TCM, Chang sha,Hunan, China
Shaofeng Yang, Hunan University of TCM, Chang sha,Hunan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.